Denileukin Diftitox, Injection

What are other names for this medicine?

Generic and brand names: denileukin diftitox, injection; Ontak

What is this medicine used for?

This medicine is given by IV infusion (through a needle into a large vein) to treat cutaneous T-cell lymphoma (a form of skin cancer).

How do I use it?

You will receive these infusions for 5 days in a row every 21 days. The number of 21-day cycles you need depends on your response to this medicine.

This medicine is given by health care providers trained in its use. You may need to stay in a hospital for the first cycle so that you can be monitored for an allergic reaction (itching, rash, or tightness or pain in your chest). Be sure that you tell your health care provider about any allergic reactions you have had to medicines in the past.

Your health care provider may tell you to take acetaminophen (Tylenol) or diphenhydramine (Benadryl) for any flulike symptoms that may occur when you receive this medicine. You can buy these products without a prescription.

What should I watch out for?

Your health care provider will order blood tests and will check your weight and blood pressure for any drastic changes. If you are not staying in the hospital, keep all your appointment for checkups and tests.

This medicine may make you dizzy. Do not drive or operate machinery unless you are fully alert.

Females of childbearing age: Tell your health care provider if you are pregnant or plan to become pregnant while receiving this medicine. Breast-feeding is not recommended while you are receiving this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your health care provider if you have any side effects that continue or get worse.

Serious (report these to your health care provider right away): Allergic reaction (itching, rash, tightness or pain in your chest), rapid or abnormal heartbeat, infection, wheezing, shortness of breath.

Other: Dizziness, nervousness, nausea, vomiting, loss of appetite, diarrhea, constipation, fever, chills, rash, hives, swelling in your feet or ankles.

What products might interact with this medicine?

No significant drug interactions have been reported.

Keep a list of all your medicines (prescription, nonprescription, supplements, natural remedies, and vitamins) with you. Be sure that you tell all health care providers who treat you about all the products you are taking.

This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your health care provider or pharmacist for more information or if you have any questions.

Keep all medicines out of the reach of children.

Do not share medicines with other people.