Orlistat, Oral

What are other names for this medicine?

Type of medicine: lipase inhibitor (treats obesity)

Generic and brand names: orlistat, oral; Xenical

What is this medicine used for?

This medicine is taken by mouth to treat obesity. It helps you lose weight and not gain it back. It works in the stomach and small intestine by blocking the absorption of fat from your food. You must follow a reduced-calorie diet for this medicine to be effective.

What should my health care provider know before I take this medicine?

Before taking this medicine, tell your health care provider if you have ever had:

• an allergic reaction to any medicine
• an eating disorder such as anorexia or bulemia
• bladder disease
• diabetes
• gallbladder problems
• malabsorption syndrome (unable to absorb or digest nutriets properly)
• thyroid or kidney disease.

Females of childbearing age: Tell your health care provider if you are pregnant or breast-feeding. Breast-feeding is not recommended while taking this medicine.

How do I use it?

Read carefully the information sheet that comes in the medicine package.

Take this medicine up to 1 hour after each main meal containing fat. Your health care provider will recommend a reduced-calorie diet in which about 30% of calories come from fat. The diet will distribute your daily intake of fat, carbohydrate, and protein over 3 main meals. If you eat a meal that is high in fat, your risk of side effects will increase.

If you miss a meal or if the meal contains no fat, you may skip the dose of medicine for that meal. If you miss taking this medicine with a meal that contains fat, you can take it up to 1 hour after your meal. But if it is more than 1 hour after your meal, wait until it's time for your next meal to take the medicine. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your health care provider.

What should I watch out for?

Because this medicine makes certain vitamins and beta-carotene less effective, you should take a multivitamin to be sure that you are getting proper nutrition. Ask your health care provider or pharmacist which multivitamin you should take. Take it once a day at least 2 hours before or after you take this medicine.

Diabetics: This medicine may affect your blood sugar level and change the amount of insulin or other diabetes medicines you may need. Talk to your health care provider about this.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your health care provider if you have any side effects that continue or get worse.

Other: Passing gas, frequent urge to move your bowels, fatty or oily stools, loss of control of bowel movements, abdominal pain, discomfort, nausea, vomiting, back pain, and fatigue.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these products together might cause harmful side effects. Talk to your health care provider if you are taking:

• cyclosporine (Sandimmune, Neoral)
• other natural remedies or medicines for weight loss
• pravastatin (Pravachol)
• vitamins A, D, E, and K
• warfarin (Coumadin).

Keep a list of all your medicines (prescription, nonprescription, supplements, natural remedies, and vitamins) with you. Be sure that you tell all health care providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.

This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your health care provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.